A lot will also be determined by your speaker cab and set up. I use Kinman AVN blues pups in the mid and neck position of my strat. There are a tad more mid rangey than standard strat pups. I have a Pearly Gates 'bucker in the bridge.
My cab is an open bacl 2x12 Avatar. Celestion vintage 30 and G12h30.
My setting preference is similar to the original post but I prefer mids (on clean tones) pretty low it just makes the tone less abrasive. I like smoooth. I play at pretty low volumes most of the time (unfortunately), so my ratio is oftern pretty low when the OD is on.
The major difference is at low volumes I usually use the bass at around 4 or 5. When louder it is too much.
Here's how it is now. Volume 5, Switches Bright and Rock on. Treble 7, Mid 1, Bass 5. Power amp master 2, and presence 7. Been playing clean mostly of late.
I have a Klein (minus those godawful ugly yellow knobs
), an EH holy grail, and Boss delay in the loop. Subtle settings on the effects.
Works for me.
And I do agree, the amp absolutley loves a Les Paul. Mine sounds killer in this rig. With it I gotta do the OD thing most of the time.
Regards