Ah...ok, so this is a self built amp and not one already built by Ceriatone. First, congrats on building the amp.
(for some reason I assumed this was not a "kit build")
I had put the heater wires down like the pictures at first too, and then moved them above later. While is was mostly subtle it did seem to be an improvement on noise and furthermore, on tone.
Please don't take this the wrong way, but are you making a clear distintion between "hiss" and "hum"? The reason I ask is that the two usually have separate reasons for being excessive. I'm assuming that since you used the term "hiss" that's what you're talking about. The other reason I'm questioning is that things like moving heater wires will be a solution for getting rid of "hum". Once again don't get me wrong. I think moving the heaters and other lead dress issues is a great idea.
Speaking of lead dress, and other then the heaters, did you follow the wiring and lead dress closely to the pictures? I'm not sure how much you have read about Dumble style amps (or amps in general) but placement of the leads can have dramatic results in the tone and noise especially V1 & V2 wiring. Make sure the cathode wires as far from the heaters as possible. Pin 3 of V2 in particular.
Also, just to reitterate again. If it's just a higher "hiss" level when cranking the OD and otherwise the amp is performing great, preamp tubes can be the biggest culprit of this. Even if it's a tube brand that usually is not an issue, sometimes some individual tubes will have a poor S/N ratio.
Good Luck & keep us updated.
If the problem persists. A few clear, in focus, close-up photos of the guts can do wonders with more experienced builders spotting any problems areas.
Glad you're liking the amp and having fun learning and building. It's a cool thing for sure.