Tone, thanks for the response.  I play mine through a Marshall 1960 (4) 12"s.  Speakers are standard issue 75's.  It's an awesome sound.  Kind of a one trick pony, but if that just on the edge of break-up with a lot of harmonics is what you like, this is for you.

I spent a lot of time trying to dial it in.  Here are the setting that I'm settled on.  Might save you some time.

Presence      5:00
Bass             8:00
Middle           7:00
Treble           6 - 7:00
Output Master   7 - 8:00
Lead Master    turn up to taste.  In the house, I'm about 2
Rhythm         I don't use this switch
Input Gain      5 - 6:00

I play through a LP R8 and a 60's player's Strat with the Custome Shop 69 PU's.

Signal path is:

Boss TU
Cry Baby
Full Drive 2
to the amp

Effects Loop

Hardwire RV - 7 reverb
Boss DD 6

Really dont need the Full Drive 2, but I like the way it throuws it over the edge.

Hope this helps.

I also have the 18 / 36 wat EF86.  I set this amp clean and play both amps at the same time in stereo.