Personally I swap between Strats & Les Pauls all the time- the OTS copes well with either- maybe a little more gain on the pre-amp with a Strat &  a little less bass with a LP that's about it... I tend to use the guitars volume & tone controls much more these days to shade my tones- I use the 'Eric Johnson' tone pot wiring on the Strat's lead pup to roll off a little high end; and much the same with the LP at times - essentially set the amp up for a good balance between clean and lead tones, then use the guitars controls to personal taste is my advice.