I had a problem with bias that go out of spect in past.
It happened to be a bad contact with powertube socket.
I didnt replace the socket, just tightened it a bit and i never had a problem with this again
.
Trough it was happening in only 1 socket/powertube.
Am not a pro but here what iwould do.
I would check for voltage of the powertubes if you can(taking REALLY care of high voltage)
So you can know if the bias circuit supply the powertube correctly, etc.
Also, i think it is recommanded to change the rectifier tube when you change the powertubes so it can be this too.